Controlled release drug delivery system of cardiovascular drug

Abstract

Conventional medication systems that require multi-dose therapy are with problems. With a view to overcome these problems, the current trend in pharmaceutical research is to design and develop new formulations, thereby enhancing the therapeutic efficacy of existing drugs. Controlled release (CR) technology has rapidly emerged over the past three decades as a new interdisciplinary science that offers novel approaches to the delivery of bioactive agents into systemic circulation at a predetermined rate. The choice of drug to be delivered, clinical needs, and drug pharmacokinetics are some of the important considerations in the development of controlled release formulation, in additions to the relation between the rates of drug release from the delivery system to the maximum achievable rate of drug absorption into the systemic circulation. By gaining, a premonation and reproduce bioactive agent release rate for an extended period of time, controlled release formulation can achieve optimum, long time efficacy, minimised toxicity and therapeutic potent responses. Controlled release pellets are manufactured either to deliver the bioactive agent at a specific site within the gastrointestinal tract or to sustain the action of drugs over an extended time period. Since these results have been achieved through the application of a functional coating materials at times the core pellets themselves have been modified to provide the desired effect.

 Key words: Controlled release, Novel approache, Pellets