Various evidences suggest that common health problem of modern society, viz. diabetes mellitus, obesity, cardiovascular diseases etc. The prevalence of diabetes mellitus in majority increases with age and obesity; over 20 % adults (≥ 60 years or older) have diabetes. Synthesis of starting materials by Noevenagel Condensation then A reaction mixture of different benzylidine propanednitriles 1a-d (10 mmol), alkylisothiourea salts (11.00 mmol) and sodium acetate anhydrous (2.50 g, 24.40 mmol) in pyridine (50 ml) was refluxed for 3 hrs, and crystallized from ethanol give compound 2a-d. then 2-Methylthiopyrimidines 2a-d (5.0 mmol) was heated under reflux overnight with 5 mL of the appropriate amine (2-phenylethylamine or cyclohexylamine, and crystallized from appropriate solvent give compound 3a-d. synthesized derivatives characterized by IR, NMR and Mass spectrophotometry and evaluated for anti-diabetic activity.
Keywords: pyrimidine, antidiabetic, Noevenagel Condensation