http://jddt.in/index.php/jddt/issue/feed Journal of Drug Discovery and Therapeutics 2021-06-15T22:38:33-04:00 JDDT-PUBLISHER editor@jddt.in Open Journal Systems <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>Journal of Drug Discovery and Therapeutics (JDDT)</strong> is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</span></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical || Dentistry || Biomedical Sciences || Ayurveda || Homeopathy || </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology, Histopathology, Toxicology and all major disciplines of Biomedical Sciences.<br /><strong>Pharmaceutical Sciences || Allied Sciences </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Very Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. JDDT only charge the fees necessary to recoup cost associated with running the journal</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Other features:</strong> DIDS Assigned and Implemented the Open Review System (ORS).</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Important Notice:</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Author can now directly send their manuscript as an email attachment to</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Innovative Library</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>editor@jddt.in</strong>, <strong>editorjddt.in@gmail.com</strong></span></span></p> <p> </p> http://jddt.in/index.php/jddt/article/view/361 AN OVERVIEW OF MUCOADHESIVE DRUG DELIVERY SYSTEM AND MUCOADHESIVE AGENTS 2021-06-03T03:38:05-04:00 Sabuj Kumar Bhattacharya sabuj.skb@gmail.com Soumya Rakshit sabuj.skb@gmail.com Souvik Mallik sabuj.skb@gmail.com Partha Sarathi Mondal sabuj.skb@gmail.com Shibam Acharya sabuj.skb@gmail.com 6Sanjoy De sabuj.skb@gmail.com Bankim Chandra Nandy sabuj.skb@gmail.com <p>Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. The mucoadhesive drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic circulation and avoiding the first pass metabolism. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several <em>in vitro </em>and <em>in vivo </em>methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion and mucoadhesive agents used in mucoadhesive drug delivery system.&nbsp;</p> <p><strong><em>Keywords: </em></strong>Mucoadhesion, Bioadhesion, mucoadhesive&nbsp; mechanism, natural mucoadhesive agents, systhetic mucoadhesive agents.</p> 2021-06-03T00:00:00-04:00 Copyright (c) 2021 Journal of Drug Discovery and Therapeutics http://jddt.in/index.php/jddt/article/view/372 COVID -19: A REVIEW ON POST COVID- 19 MANIFESTATIONS AND COMPLICATIONS 2021-06-15T22:38:33-04:00 Subanthu Arya aryasurya29@gmail.com K. Sreejith aryasurya29@gmail.com V.K Thamanna aryasurya29@gmail.com M. Salim Asna aryasurya29@gmail.com Sabnam Maziya aryasurya29@gmail.com Paul Kiran Mary aryasurya29@gmail.com <p>COVID -19 (corona virus disease 19) or SARS-COV-2 (severe acute respiratory syndrome coronavirus 2) is an emerging infectious disease spreading worldwide. Symptoms may varies person to person. In some patients due to the increased release of inflammatory cytokines&nbsp;disease may progress to pneumonia, respiratory failure or even death. Studies identified the entry of virus to the respiratory mucosa is through the angiotensin receptor 2 (ACE2). Coronaviruses are mainly divided into four types based on the structural genomics as α, β, γ, and δ. Middle east respiratory syndrome corona virus(mers-cov) and severe acute respiratory syndrome 2(sars-cov2) comes under beta coronaviruses. As COVID-19 is an ongoing crisis faced by the world, knowledge on various aspects of COVID -19 is essential. Recent studies evinced the post covid-19 complications following acute covid-19 infections. &nbsp;A multitude of complications are faced by patients after acute infectious period of COVID-19, for instance neurological, respiratory, cardiovascular, hematological, gastrointestinal and ophthalmological manifestations and complications. Almost all systems are affected by SARS-COV2 virus hence post covid follow-up checkup should be encouraged for all covid -19 recovered patients. The emergence of post covid care centres or clinics should be promoted in order to reduce the subsequent sufferings accompanied with COVID-19 recovery. This review summarises the various post covid-19 manifestations and complications.</p> <p><strong>Keywords: </strong>Covid -19, SARS-COV-2, Post covid -19 complications</p> 2021-06-15T00:00:00-04:00 Copyright (c) 2021 Journal of Drug Discovery and Therapeutics http://jddt.in/index.php/jddt/article/view/370 A REVIEW ON IMPACT OF PSYCHOLOGICAL STRESS IN IMMUNE RESPONSES IN DIFFERENT PATHOLOGICAL AND PHYSIOLOGICAL CONDITIONS 2021-06-15T22:25:54-04:00 Paul Kiran Mary kiranmary1997@gmail.com K Sreejith kiranmary1997@gmail.com Subanthu Arya kiranmary1997@gmail.com V K Thamanna kiranmary1997@gmail.com M Asna Salim kiranmary1997@gmail.com Sabnam Maziya kiranmary1997@gmail.com <p>Stress is the common psychological discomfort. Stress generally physical, psychological, acute stress and chronic stress. The factors which cause the mental stress are called stressors. Stress can affect various organ systems in our body.</p> <p>Mental stress may alter immune system and cause vulnerability to infections. It affects both cell mediated and humoral immunity.</p> <p>Physical and psychological stress causes the activation of Hypothalamic pituitary adrenal axis. And hypothalamus increase the release of corticotrophin releasing hormone [CRH] and anterior pituitary release adrenocorticotrophin hormone. Thus, increase serum levels of corticosteroids.</p> <p>Psychological stress can promote the infectious diseases like tuberculosis. Also, Herpes simplex and Epstein Barr virus infection may re-activate because of mental stress.</p> <p>The psychological stress has high impact on immune system in various levels. Because novel diseases like COVID – 19 largely effected by psychological stress. The research and practice on stress reduction techniques are highly relevant can be considered as useful prevention method.</p> <p><strong>Keywords: </strong>Psychological stress, Immune system</p> 2021-06-15T00:00:00-04:00 Copyright (c) 2021 Journal of Drug Discovery and Therapeutics http://jddt.in/index.php/jddt/article/view/362 A REVIEW ON CONSEQUENCES OF SELF MEDICATION 2021-06-03T03:54:29-04:00 V.K. Thamanna thamanna7594@gmail.com K. Sreejith thamanna7594@gmail.com Subanthu Arya jithuspharma@gmail.com M.Salim Asna jithuspharma@gmail.com Paul Kiran Mary jithuspharma@gmail.com Sabnam Maziya jithuspharma@gmail.com <p>Use of drugs without medical guidance may lead to problems like inappropriate, incorrect, or undue therapy, missed diagnosis, delays in appropriate treatment, pathogen resistance and increased morbidity. Studies shows that self medication practice is common for disease conditions like headache, common cold, fever, cogh and respiratory infections. &nbsp;Self medication should be considered as an emerging problem because there are occurances of a lot of risks. dispensing modes of OTC drugs needs to be improved through proper education, strict managerial and regulatory strategies.</p> <p><strong>Keywords: </strong>OTC drugs, SMP (self medication practice), antibiotic resistance, OTC drug abuse</p> 2021-06-03T00:00:00-04:00 Copyright (c) 2021 Journal of Drug Discovery and Therapeutics http://jddt.in/index.php/jddt/article/view/371 OBESITY AND COVID 19-TWO INTERCONNECTED PANDEMICS 2021-06-15T22:33:33-04:00 Sabnam Maziya maziyasabnam@gmail.com K. Sreejith maziyasabnam@gmail.com Subanthu Arya maziyasabnam@gmail.com M Salim Asna maziyasabnam@gmail.com <p>Corona virus disease commonly known as COVID-19 is a severe pandemic that has spread globally causing large number of deaths till date. Obesity is a disease caused due to excessive fat accumulation in the body. High calorie diet intake and lack of physical activity has increased obesity at an alarming rate causing it to reach pandemic proportions worldwide. An interrelationship exists between these diseases.&nbsp; On one hand, obesity has emerged as an important risk factor of disease severity in COVID-19 while one the other hand, worldwide spread of COVID-19 and increased treatment requirements have resulted in less attention to other non-communicable diseases including obesity. This study reviews both the role of obesity as a risk factor of COVID-19 and the&nbsp;&nbsp; negative impact of COVID-19 pandemic on obesity incidence and care. The study analyses the effect of obesity&nbsp;&nbsp; on COVID-19 complications including recovery time, ICU admission, IMV requirement, poor outcomes and death. The review also takes into account the role of obesity on COVID-19 vaccine efficacy.</p> <p><strong>Keywords:</strong> COVID-19, Obesity, Risk factor, pandemic</p> 2021-06-15T00:00:00-04:00 Copyright (c) 2021 Journal of Drug Discovery and Therapeutics http://jddt.in/index.php/jddt/article/view/369 BREAST CANCER; A REVIEW ON THE ROLE OF MiRNAs IN DISEASE PROGRESSION AND DRUG RESISTANCE 2021-06-15T22:13:00-04:00 M.Salim Asna asnasalimm123456@gmail.com K Sreejith asnasalimm123456@gmail.com Subanthu Arya asnasalimm123456@gmail.com V.K Thamanna asnasalimm123456@gmail.com Sabnam Maziya asnasalimm123456@gmail.com Paul Kiran Mary asnasalimm123456@gmail.com <p>Breast cancer is one among the most common types of cancer in women and is a leading cause of death. Early diagnosis and management of breast cancer has decreased the death rates due to breast cancer. The current treatment strategy for breast cancer combines surgery with radiotherapy, chemotherapy, targeted therapy and hormonal therapy. However, factors like relapse and drug resistance serve as major challenges in the successful management of this disease. . The recent studies identify the involvement of miRNAs in breast cancer development and drug resistance. MiRNAs are non-coding, single stranded RNAs that are composed of 20-25 nucleotide sequences. MiRNAs binds to the 3’ untranslated areas of the target mRNA and mediate the gene expression at post transcriptional level. The aberrant expression of miRNAs leads to deregulation of gene expression and may result in drug resistance. The altered miRNA plays a vital role in metastasis, drug resistance and tumorigenesis. MiRNAs are involved in most of the major signaling mechanisms of our body and has a pivotal role in the development of neurological disorders, cardiovascular disorders, autoimmune disorders as well as various types of cancers like breast cancer. Recent studies also explore the potential of miRNAs as drug targets, biomarkers and therapeutic agents. In this review, we describe the role of miRNAs in chemotherapy resistance and disease development with special emphasis to the mechanisms involved. MiRNAs associated with the development of resistance to hormonal therapy is also being discussed here.</p> <p><strong>Keywords:</strong> Breast cancer , microRNAs,&nbsp; drug resistance</p> 2021-06-15T00:00:00-04:00 Copyright (c) 2021 Journal of Drug Discovery and Therapeutics