http://jddt.in/index.php/jddt/issue/feed Journal of Drug Discovery And Therapeutics 2019-03-23T05:22:52-05:00 Editor-in- Chief editor@jddt.in Open Journal Systems <p>&nbsp;</p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>Journal of Drug Discovery and Therapeutics (JDDT)</strong> is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</span></span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical || Dentistry || Biomedical Sciences&nbsp;|| Ayurveda&nbsp;|| Homeopathy&nbsp;||&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology,&nbsp;Histopathology, Toxicology and all major disciplines of Biomedical Sciences.</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Pharmaceutical Sciences || Allied Sciences&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical&nbsp; Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <hr> <p style="text-align: justify;">&nbsp;</p> http://jddt.in/index.php/jddt/article/view/447 RAPID IN VITRO PROPAGATION OF WESTERN GHATS CULTIVAR - COLOCASIA ESCULENTA FOR THE HIGH FREQUENCY OF PLANTLETS 2019-03-23T05:22:52-05:00 Jyothi R paps_20052005@rediffmail.com Srinivasa Murthy K M paps_20052005@rediffmail.com Hossein . paps_20052005@rediffmail.com Veena . paps_20052005@rediffmail.com <p><em>Colocasia esculenta</em> is commonly known as Taro, it is referred to as cocoyam in Nigeria. They are cherished for their rich taste, nutritional and medicinal properties. Every 100 g of taro corms possess 112 Kcal, 26.46 g carbohydrate, 1.50 g protein, 0.20 g total fat and 4.1g fiber (USDA National Nutrient Data Base). Besides its nutritional value, taro is used as a medical plant and provides bioactive compounds used as an anti-cancer drugs. Traditionally, cocoyams are vegetative propagated from tuber fragments, a practice that encourages pathogen distribution. <em>Colocasia esculenta</em> is a widely distributed food crop in the humid tropics and subtropics. Despite of its wide distribution, Taro plants are commonly infected with DsMV and other pathogens.&nbsp;This virus induces conspicuous mosaic, malformation, dwarfing or feathering on leaves in taro. As the results of infection, it reduces the quality and yield of taro production greatly. This virus is thus considered as a major limiting factor in the production of taro. Here plays the importance of &nbsp;tissue culture plays a major role in producing the disease resistant plants round the year with high quality. For rapid multiplication and production of quality planting materials, tissue culture technology offers promising alternative compared to the traditional production methods.</p> <p><strong>KEYWORDS</strong>: <em>Colocasia esculenta</em>, Virus, Pathogens, Conventional propagation, Micropropagation, Yield, Rapid multiplication, Quality</p> 2019-02-18T08:12:56-06:00 ##submission.copyrightStatement## http://jddt.in/index.php/jddt/article/view/449 A NOVEL MERCURIMETRIC TITRATION ASSAY OF METFORMIN HYDROCHLORIDE USING MERCURY (II) THIOCYANATE–IRON (III) NITRATE INDICATOR SYSTEM 2019-03-02T02:32:26-06:00 S. R. Labhade srlabhade3571@rediffmail.com H. S. Labhade srlabhade3571@rediffmail.com V. B. Kadam srlabhade3571@rediffmail.com V. B. Gaikwad srlabhade3571@rediffmail.com <p>A simple, rapid, reliable and novel titration procedure for the mercurimetric assay of metformin hydrochloride (MHCl) based on measurement of the chloride content of its hydrochloride salt is described. In this experiment, initially a synthetic mercury(II) thiocyanate [Hg(SCN)<sub>2</sub>] indicator was prepared by titrating mercury(II) nitrate [Hg(NO<sub>3</sub>)<sub>2</sub>] against potassium thiocyanate (KSCN) in the 1:2 stoichiometric ratio using ferric nitrate [Fe(NO<sub>3</sub>)<sub>3</sub>]. After addition of a known amount of Hg(NO<sub>3</sub>)<sub>2</sub> to the indicator, the solution was further titrated against the aqueous solution of MHCl until the original red color reappeared. The concentration of chloride present in the volume (of MHCl) utilized for the reaction was found to be reacting in the 2:1 stoichiometric ratio with the Hg(NO<sub>3</sub>)<sub>2 </sub>taken in the second titration. The statistical treatment of the experimental data obtained by determining MHCl in the concentration range 0.8281 to 8.281 g/lit, indicates that the procedure is precise and accurate. The procedure was further applied for the analysis of MHCl in tablet formulations. The average recovery and accuracy were found to be in agreement with claimed by the manufacturer. The common excipients&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;used in tablet formulations did not interfere in the determination of MHCl by this procedure as observed by the recovery experiment using standard addition method. The chemistry involved in titration, the action of an indicator at the end point and the factors that affecting the reaction stoichiometry are discussed.</p> <p><strong>Keywords:</strong> Chloride assay, Mercurimetric titration, Mercury (II) nitrate, Mercury(II) thiocyanate-iron(III) nitrate indicator system, Metformin hydrochloride, Metformin hydrochloride tablets.</p> 2019-03-02T02:27:57-06:00 ##submission.copyrightStatement##