Journal of Drug Discovery And Therapeutics 2018-10-17T02:50:57+00:00 Editor-in- Chief Open Journal Systems <p>Journal of Drug Discovery and Therapeutics &nbsp;(JDDT)&nbsp;(ISSN : 2320 – 4230)&nbsp;is Monthly international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</p> COMPARISON OF ANTIHYPERTENSIVE EFFECT OF MOXONIDINE VERSUS CLONIDINE IN RENAL FAILURE PATIENTS. 2018-10-17T02:50:57+00:00 DR.MATHEW GEORGE DR.LINCY JOSEPH MRS.DEEPTHI MATHEW ALISHA MARIA SHAJI BIJI JOSEPH STEFFI SARA SAM <p>Blood pressure is the force of blood pushing against blood vessel walls as the heart pumps out blood, and high blood pressure, also called&nbsp;<a href="">hypertension</a>, is an increase in the amount of force that blood places on blood vessels as it moves through the body. Factors that can increase this force include higher blood volume due to extra fluid in the blood and blood vessels that are narrow, stiff, or clogged<sup>(1)</sup>.</p> <p>High blood pressure can damage blood vessels in the kidneys, reducing their ability to work properly. When the force of blood flow is high, blood vessels stretch so blood flows more easily. Eventually, this stretching scars and weakens blood vessels throughout the body, including those in the kidneys.</p> 2018-09-30T12:33:27+00:00 ##submission.copyrightStatement##