Journal of Drug Discovery And Therapeutics http://jddt.in/index.php/jddt <p>&nbsp;</p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>Journal of Drug Discovery and Therapeutics (JDDT)</strong> is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</span></span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical || Dentistry || Biomedical Sciences&nbsp;|| Ayurveda&nbsp;|| Homeopathy&nbsp;||&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology,&nbsp;Histopathology, Toxicology and all major disciplines of Biomedical Sciences.</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Pharmaceutical Sciences || Allied Sciences&nbsp;</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical&nbsp; Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <hr> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <hr> <p style="text-align: justify;">&nbsp;</p> en-US editor@jddt.in (Editor-in- Chief) editor@jddt.in (Executive Editor) Tue, 21 May 2019 11:05:38 -0500 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 EFFECTS OF LEUCAS CEPHALOTES EXTRACT ON INSULIN RESISTANCE AND ASSOCIATED METABOLIC SYNDROME IN TYPE II DIABETIC RATS http://jddt.in/index.php/jddt/article/view/451 <p><strong><em>Background:</em></strong> Type II diabetes is the most common metabolic disorder caused by inadequate insulin secretion by pancreatic β-cells to compensate for insulin resistance in peripheral tissues, which leads microvascular and macrovascular complications. Novel treatment strategies for the management of insulin resistance and associated metabolic syndromes,&nbsp; plant based medicines contributing much with minimal side effects like lactic acidosis.</p> <p><strong><em>Objective</em></strong><strong>:</strong> As Insulin resistance and associated metabolic syndrome contributes to the pathogenesis of type 2 diabetes mellitus,&nbsp; we investigated whether methanolic extract of whole plant <em>Leucas cephalotes </em>(MELC) plays any role in preventing type-2 diabetes mellitus and associated metabolic syndrome in streptozotocin (STZ) induced diabetic rats.</p> <p><strong><em>Materials and Methods</em></strong><strong>:</strong> The MELC was prepared by solvent extraction procedure. Rat pups of age 5 days were divided into 4 groups, with 6 animals in each. <strong>Group-I</strong> pups served as vehicle control and received 1% sodium carboxy methyl cellulose (CMC), <strong>Group-II</strong> served as diabetic control and was treated only with single dose of streptozotocin (80mg/kg, <em>i.p</em>), <strong>Group-III</strong> &amp; <strong>Group-IV</strong> served as test groups were treated with MELC at doses of 150mg/kg and 300mg/kg respectively for about 45 days after single dose administration of STZ (80mg/kg, <em>i.p</em>). On 30<sup>th</sup> and 45th day, blood samples were collected from all animals and levels of fasting glucose, fasting insulin, uric acid, Hydrogen Sulphide (H<sub>2</sub>S), triglycerides and total cholesterol levels in plasma were estimated.</p> <p><strong><em>Results</em></strong><strong>:</strong> The plasma fasting glucose levels were found to be significantly (p&lt;0.001) elevated in single dose streptozotocin treated diabetic control than vehicle control. However, in low dose and high dose test groups, fasting glucose levels, fasting insulin levels, insulin resistance, all the biochemical parameters associated with metabolic syndrome such as fasting insulin values, Triglyceride, Total cholesterol, H<sub>2</sub>S and Uric acid levels were significantly (p&lt;0.01and p&lt;0.001) decreased after chronic administration of MELC for 45 days and the decrease was more prominent with higher dose. &nbsp;&nbsp;</p> <p><strong><em>Conclusions</em></strong><strong>:</strong> The present investigation reveals that MELC administration shows significant effect on insulin resistance and associated metabolic syndrome in a dose dependent manner. So, hereby the beneficial action of MELC on human type-II diabetes may be suggested.</p> <p><strong>Keywords:</strong> <em>Leucas cephalotes;</em> Insulin resistance; metabolic syndrome; Streptozotocin; Type-2 Diabetes mellitus.</p> Rama Narsimha Reddy A, Lavanya V, Ramdhan G, Baburao B ##submission.copyrightStatement## http://jddt.in/index.php/jddt/article/view/451 Tue, 21 May 2019 00:00:00 -0500