Evaluation and Development of Domperidone Mucoadhesive Patches for Buccal Drug Delivery

Authors

  • Abhinav Srivastava P.G Research Scholar, Faculty of Pharmacy, P.K. University, Shivpuri (M.P.), India
  • G Pavan Kumar Professor, Faculty of Pharmacy, P.K. University, Shivpuri (M.P.), India
  • Jitendra Malik Professor, Faculty of Pharmacy, P.K. University, Shivpuri (M.P.), India
  • Gyan Singh Associate Professor, Faculty of Pharmacy, P.K. University, Shivpuri (M.P.), India
  • Anadi Tiwari Assistant Professor, Faculty of Pharmacy, P.K. University, Shivpuri (M.P.), India
  • Vinay Kumar Siroliya Assistant Professor, Faculty of Pharmacy, P.K. University, Shivpuri (M.P.), India

Abstract

Mucoadhesion is a state in which two components, one of which is of biological origin, are held together for extended periods of time with the assistance of interfacial forces. This state can be characterized as mucoadhesion. The buccal mucosa has excellent accessibility and is rather immobile, making it suited for the administration of retentive dosage forms. Comparatively speaking, the other transmucosal routes do not possess these characteristics. From a theoretical vantage point, the purpose of this paper is to conduct a review of the work that has been done in the subject of mucoadhesive buccal drug delivery systems, abbreviated MBDDS. This article begins with a brief introduction of the mucoadhesive drug delivery systems, oral mucosa, and the theories of mucoadhesion. It then proceeds to detail the works that have been done so far in the field of MBDDS, categorizing them depending on what they are intended to treat. In addition, we concentrate on the numerous patents, recent advancements, and obstacles in the field, as well as the opportunities that exist for mucoadhesive buccal drug delivery systems.

Keywords: buccal mucosa, clinical perspective, mucoadhesion, patents, transmucosal route.

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Published

2023-08-30

Issue

Vol. 11 No. 4 (2023): July-August

Section

Articles