https://jddt.in/index.php/jddt/issue/feed Journal of Drug Discovery and Therapeutics 2021-10-07T10:14:59-04:00 JDDT-PUBLISHER editor@jddt.in Open Journal Systems <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>Journal of Drug Discovery and Therapeutics (JDDT)</strong> is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</span></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical || Dentistry || Biomedical Sciences || Ayurveda || Homeopathy || </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology, Histopathology, Toxicology and all major disciplines of Biomedical Sciences.<br /><strong>Pharmaceutical Sciences || Allied Sciences </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Very Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. JDDT only charge the fees necessary to recoup cost associated with running the journal</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Other features:</strong> DIDS Assigned and Implemented the Open Review System (ORS).</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Important Notice:</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Author can now directly send their manuscript as an email attachment to</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Innovative Library</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>editor@jddt.in</strong>, <strong>editorjddt.in@gmail.com</strong></span></span></p> <p> </p> https://jddt.in/index.php/jddt/article/view/396 Formulation and Evaluation of Elementary Osmotic Antidepressant Capsule 2021-09-28T08:20:05-04:00 Giri Raj editor@jddt.in Vivek Patel editor@jddt.in Pratyush Jain editor@jddt.in Alok Pal Jain editor@jddt.in <p>The oral route of administration is considered as the most widely accepted route but the most evident drawback of the commonly used oral dosage forms like tablets and capsules is difficulty in swallowing, leading to patient’s incompliance particularly in case of paediatric, geriatric patients, dysphasic, bed ridden, and psychic patients. Thus, a new delivery system developed as in situ pore former osmotic drug delivery system. The purpose of present research work was to develop osmotic drug delivery of Imipramine. Imipramine has been selected as a model drug to study the effect of <em>in-situ</em>pore former osmotic capsule because is a tricyclic antidepressant mainly used in the treatment of depression.&nbsp;</p> <p><strong>Keywords:</strong> Osmotic, Capsule, Drug</p> 2021-09-28T00:00:00-04:00 Copyright (c) 2021 Journal of Drug Discovery and Therapeutics https://jddt.in/index.php/jddt/article/view/397 A Review on Childhood Obesity 2021-10-04T02:04:42-04:00 Sabnam Maziya maziyasabnam@gmail.com K. Sreejith maziyasabnam@gmail.com Subanthu Arya maziyasabnam@gmail.com M Salim Asna maziyasabnam@gmail.com V.K Thamanna maziyasabnam@gmail.com Paul Kiranmary maziyasabnam@gmail.com <p>Obesity is a condition characterised by excess accumulation of fat in the body. Childhood obesity is a state in which a child is remarkably overweight for his or her age and height. Childhood obesity is defined as a BMI greater than or equal to 95<sup>th</sup> percentile for children and teens of same age and sex. Childhood obesity is caused due to a complex interaction between number of factors including genetic, environmental, ecological, socio-cultural, and psychological factors. Clinical evaluation is done to identify the cause of obesity and obesity-related comorbidities. The evaluation consists of physical examination and complete history examination. Childhood obesity is associated with a number of consequences including immediate health issues and future risks. A staged approach is recommended in the treatment of obesity. initial management is carried out in primary care with focus on healthy dietary habits and increase physical activity. Those not showing response to primary care interventions or having significant health risks should be managed by a multidisciplinary team with expertise in childhood obesity. Pharmacotherapy or bariatric surgery is considered if there is no response to weight management.</p> <p><strong>KEYWORDS</strong>: Childhood obesity, pediatric obesity, causes, consequences, treatment</p> 2021-10-04T00:00:00-04:00 Copyright (c) 2021 Journal of Drug Discovery and Therapeutics https://jddt.in/index.php/jddt/article/view/398 Covid -19: A Review on Covid- 19 Vaccines in India 2021-10-05T00:16:08-04:00 Subanthu Arya editor@ijmbs.info K. Sreejith editor@ijmbs.info V.K Thamanna editor@jddt.in M. Salim Asna editor@jddt.in Sabnam Maziya editor@jddt.in Paul Kiran Mary editor@jddt.in <p>COVID -19 (corona virus disease 19) or SARS-COV-2 (severe acute respiratory syndrome coronavirus 2) is an emerging infectious disease spreading worldwide. Since there is no medicines discovered against covid -19, vaccines are developed by various manufacturers in a short duration without compromising the safety due to the urgency of vaccines during the pandemic and many vaccines are at the stage of clinical trials. Even though many vaccines are developed, less number of vaccines only got the approval. Various covid 19 vaccines are available in India mainly covishield and covaxin. Vaccination for COVID-19 is very essential as&nbsp;&nbsp; vaccination&nbsp;&nbsp; has&nbsp;&nbsp; proved&nbsp;&nbsp; to&nbsp;&nbsp; decrease severity and prevent mortality due to COVID-19. All people should be vaccinated at the earliest to reduce the impact and severity of covid -19. so, information’s regarding covid -19 should be addressed to the public for removing the barriers which prevent them from taking vaccines. Many people are not yet vaccinated due to the misconceptions about vaccines and adverse events following immunization. This article contains a detailed review of vaccines currently available in India.</p> <p>Keywords: Covid -19, Vaccines, Adverse Events, Covaxin, Covishield, Immunisation</p> 2021-10-05T00:00:00-04:00 Copyright (c) 2021 Journal of Drug Discovery and Therapeutics https://jddt.in/index.php/jddt/article/view/399 A Review on Various Gastro-Intestinal Effects of Mental Stress and Management 2021-10-05T03:05:14-04:00 Paul Kiran Mary editor@jddt.in K Sreejith editor@jddt.in Subanthu Arya editor@jddt.in V K Thamanna editor@jddt.in M Asna Salim editor@jddt.in Sabnam Maziya editor@jddt.in <p>Stress is caused by the situation, person cannot capable to cope with that unfavourable event and person’s judgment not capable to suit the demand of that event. Symptoms of stress includes Depression, anxiety. Anger, irritability, restlessness. Feeling overwhelmed, unmotivated, or unfocused, Trouble sleeping or sleeping too much, Racing thoughts or constant worry, Problems with your memory or concentration, Making bad decisions etc. The physiological actions in gut are controlled by the Enteric nervous system [ part of central nervous system]. ENS carry millions of nerve cells as sensory motor and interneurons. They have sympathetic and para-sympathetic links. After the stress stimulus is delayed and reach Hypothalamic- pituitary – adrenal axis [ HPA axis] is producing Corticotrophin Releasing Factor (CRF). It directly produces some effects on gut like Changes in permeability of gut, Hypersensitivity to pain in visceral portion of gut, Increase chance of inflammation, Changes in gut motility, Gut microbiota transformation etc. The gastro-intestinal diseases like peptic ulcer, GERD, Inflammatory bowel disease, Irritable-bowel syndrome are produced. Techniques likes Yoga, meditation, physical exercises produce prevention and reduction of stress. In case of gastro- intestinal disorders some anxiolytics, ulcer- protectives, food changes can manage complications.&nbsp;</p> <p><strong>Keywords:</strong> Psychological stress, gastro-intestinal effects, Cortisol, Management techniques.</p> 2021-10-04T00:00:00-04:00 Copyright (c) 2021 https://jddt.in/index.php/jddt/article/view/400 A Review on Focal Problems of Breast Cancer Treatment and the Need for Rehabilitation 2021-10-07T09:51:04-04:00 M.Salim Asna asnasalimm123456@gmail.com K Sreejith asnasalimm123456@gmail.com Subanthu Arya asnasalimm123456@gmail.com V.K Thamanna editor@ijmbs.info Sabnam Maziya asnasalimm123456@gmail.com Paul Kiran Mary asnasalimm123456@gmail.com <p>Breast cancer is the most malignant cancer in women around the globe. With the advent of diagnostic tools and novel methods of therapy, the mortality rate is now under control and the number of breast cancer survivors has improved. But unfortunately, the local therapies cause serious after effects like persistent pain in the breast area, arm and shoulder, lymphedema and restrictions of arm and shoulder movement. It can also cause psychological and social problems.Unfortunately, little attention has been paid to late effects of breast cancer that can persist for several years. This not only has diminished the quality of life of patients but also have increased the cost of life.&nbsp; In this article, we focus on the management of breast cancer and the focal problems associated with the same. Also we discuss about the need for rehabilitation and the type of rehabilitation techniques.</p> <p><strong>Keywords</strong>: Breast cancer, late effects of breast cancer, rehabilitation</p> 2021-10-07T00:00:00-04:00 Copyright (c) 2021 https://jddt.in/index.php/jddt/article/view/401 A REVIEW ON SELF MEDICATION IN GERIATRICS 2021-10-07T10:14:59-04:00 V.K. Thamanna thamanna7594@gmail.com K. Sreejith thamanna7594@gmail.com Subanthu Arya thamanna7594@gmail.com M.Salim Asna thamanna7594@gmail.com Paul Kiran Mary thamanna7594@gmail.com Sabnam Maziya thamanna7594@gmail.com <p>Self medication is the practice of using drugs without doctor’s prescription. Nowadays this behavior is growing widely among people and the prevalence is high. As increasing age, body changes can affect the way medicines are absorbed and used. Geriatric population are more prone to use self medication practice due to lack of knowledge and commonly used for diseases like allergic rhinitis, common cold, osteoarthritis, heartburn, insomnia, constipation etc. Polypharmacy should be avoided. In situations where communication is lacking and the patient may receive medications from multiple prescribers for similar conditions, polypharmacy is particularly likely to occur. There is a need to develop a treatment infrastructure that is sensitive to problems of older substance users. This should include education of professionals as well as that of the public at large.</p> <p><strong>Keywords: </strong>self medication practice, polypharmacy, multimorbidity, pathogen resistance</p> 2021-10-07T00:00:00-04:00 Copyright (c) 2021