Journal of Drug Discovery and Therapeutics https://jddt.in/index.php/jddt <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>Journal of Drug Discovery and Therapeutics (JDDT)</strong> is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</span></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical || Dentistry || Biomedical Sciences || Ayurveda || Homeopathy || </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology, Histopathology, Toxicology and all major disciplines of Biomedical Sciences.<br /><strong>Pharmaceutical Sciences || Allied Sciences </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Very Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. JDDT only charge the fees necessary to recoup cost associated with running the journal</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Other features:</strong> DIDS Assigned and Implemented the Open Review System (ORS).</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Important Notice:</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Author can now directly send their manuscript as an email attachment to</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Innovative Library</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>editor@jddt.in</strong>, <strong>editorjddt.in@gmail.com</strong></span></span></p> <p> </p> JDDT en-US Journal of Drug Discovery and Therapeutics 2320-4230 Formulation and Evaluation of Mouth Dissolving Tablets of Montelukast Sodium https://jddt.in/index.php/jddt/article/view/405 <p>Convenience of administration and increased patient compliance are critical factors in the design of oral drug delivery systems, which continue to be the dominant route of drug delivery despite several drawbacks. Mouth dissolving tablets (MDTs) have grown in popularity over the past decade, and the sector has developed into a fast-growing segment of the pharmaceutical business. Due to the formulation's popularity and use, various MDT technologies have been developed. These procedures enable to dissolve in the mouth in five seconds without the need for chewing or water, which is very beneficial for children, geriatrics, and people who have difficulty swallowing tablets and capsules. By addressing swallowing difficulties and limited patient compliance, the formulation of an appropriate dose form for administration results in the production of mouth dissolving tablets. There are various traditional ways of preparation of MDTs, however new technologies have been created for the manufacturing of mouth dissolving tablets.</p> <p><strong>Keywords:</strong> MDTs, Montelukast Sodium</p> Arindam Chatterjee Ashutosh Sharma Ombir Copyright (c) 2021 Journal of Drug Discovery and Therapeutics 2021-10-30 2021-10-30 9 10 Solubility Enhancement of Poorly Water- Soluble Drugs Using Solid Dispersion Method: A Review https://jddt.in/index.php/jddt/article/view/406 <p>Solid dispersions have generated substantial attention as a technique of increasing the dissolution rate and hence the bioavailability of a variety of medications that are poorly soluble in water. Today, the pharmaceutical industry discovers up to 40% of novel chemical entities that are poorly soluble or lipophilic. Solid dispersions of insoluble in water pharmaceuticals in water-soluble carriers significantly minimise the occurrence of these difficulties and improve dissolution. Solid dispersion is one of the most promising methods for increasing solubility. The phrase "solid dispersion" refers to a collection of solid goods that have at least two distinct components, most often a hydrophilic matrix and a hydrophobic medication. The matrix might be crystalline or amorphous in nature. Class II medicines with limited solubility and high permeability are attractive candidates for bioavailability enhancement by solid dispersion, according to the biopharmaceutical categorization system. The purpose of this paper is to explore current achievements in the field of solid dispersion.</p> <p><strong>Keywords: </strong>Solid dispersions, solubility, carrier, Biopharmaceutical classification system.</p> Mayank Bansal Sunil Sain Nitin Garg Copyright (c) 2021 Journal of Drug Discovery and Therapeutics 2021-10-30 2021-10-30 9 10