Journal of Drug Discovery and Therapeutics https://jddt.in/index.php/jddt <p><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><span style="text-align: justify;"><strong>Journal of Drug Discovery and Therapeutics (JDDT)</strong> is an international, peer-reviewed, open access, online journal dedicated to the rapid publication of full-length original research papers, short communications, invited reviews, Case studies and editorial commentary and news, Opinions &amp; Perspectives and Book Reviews written at the invitation of the Editor in all areas of the Biomedical and Pharmaceutical Sciences.</span></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Medical || Dentistry || Biomedical Sciences || Ayurveda || Homeopathy || </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Anatomy, Physiology, Biochemistry, Molecular Biology, Cell biology, Genetics, Hematology, Pathology, Immunology, Microbiology, Virology, Parasitology, Surgery, Dental Sciences, Sports Physiology, Histopathology, Toxicology and all major disciplines of Biomedical Sciences.<br /><strong>Pharmaceutical Sciences || Allied Sciences </strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Toxicology, Pharmaceutical and Biomedical Analysis, Clinical Research, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology and all major disciplines of Pharmaceutical Sciences.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;">Articles are published as they are accepted and are freely available on the journal’s website to facilitate rapid and broad dissemination of research findings to a global audience.</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Top Reasons for publication with us</strong></span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Quick Quality Review:</strong> The journal has strong international team of editors and reviewers, Rapid Decision and Publication</span></span></p> <p style="text-align: justify;"><span style="font-family: lucida sans unicode,lucida grande,sans-serif;"><span style="font-size: 14px;"><strong>Very Low Publication Fees:</strong> Comparable journals charge a huge sum for each accepted manuscript. 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LIB) Tue, 28 Sep 2021 08:27:02 -0400 OJS 3.2.1.1 http://blogs.law.harvard.edu/tech/rss 60 Formulation and Evaluation of Elementary Osmotic Antidepressant Capsule https://jddt.in/index.php/jddt/article/view/396 <p>The oral route of administration is considered as the most widely accepted route but the most evident drawback of the commonly used oral dosage forms like tablets and capsules is difficulty in swallowing, leading to patient’s incompliance particularly in case of paediatric, geriatric patients, dysphasic, bed ridden, and psychic patients. Thus, a new delivery system developed as in situ pore former osmotic drug delivery system. The purpose of present research work was to develop osmotic drug delivery of Imipramine. Imipramine has been selected as a model drug to study the effect of <em>in-situ</em>pore former osmotic capsule because is a tricyclic antidepressant mainly used in the treatment of depression.&nbsp;</p> <p><strong>Keywords:</strong> Osmotic, Capsule, Drug</p> Giri Raj, Vivek Patel, Pratyush Jain, Alok Pal Jain Copyright (c) 2021 Journal of Drug Discovery and Therapeutics https://jddt.in/index.php/jddt/article/view/396 Tue, 28 Sep 2021 00:00:00 -0400 A Review on Childhood Obesity https://jddt.in/index.php/jddt/article/view/397 <p>Obesity is a condition characterised by excess accumulation of fat in the body. Childhood obesity is a state in which a child is remarkably overweight for his or her age and height. Childhood obesity is defined as a BMI greater than or equal to 95<sup>th</sup> percentile for children and teens of same age and sex. Childhood obesity is caused due to a complex interaction between number of factors including genetic, environmental, ecological, socio-cultural, and psychological factors. Clinical evaluation is done to identify the cause of obesity and obesity-related comorbidities. The evaluation consists of physical examination and complete history examination. Childhood obesity is associated with a number of consequences including immediate health issues and future risks. A staged approach is recommended in the treatment of obesity. initial management is carried out in primary care with focus on healthy dietary habits and increase physical activity. Those not showing response to primary care interventions or having significant health risks should be managed by a multidisciplinary team with expertise in childhood obesity. Pharmacotherapy or bariatric surgery is considered if there is no response to weight management.</p> <p><strong>KEYWORDS</strong>: Childhood obesity, pediatric obesity, causes, consequences, treatment</p> Sabnam Maziya, K. Sreejith, Subanthu Arya, M Salim Asna, V.K Thamanna, Paul Kiranmary Copyright (c) 2021 Journal of Drug Discovery and Therapeutics https://jddt.in/index.php/jddt/article/view/397 Mon, 04 Oct 2021 00:00:00 -0400 Covid -19: A Review on Covid- 19 Vaccines in India https://jddt.in/index.php/jddt/article/view/398 <p>COVID -19 (corona virus disease 19) or SARS-COV-2 (severe acute respiratory syndrome coronavirus 2) is an emerging infectious disease spreading worldwide. Since there is no medicines discovered against covid -19, vaccines are developed by various manufacturers in a short duration without compromising the safety due to the urgency of vaccines during the pandemic and many vaccines are at the stage of clinical trials. Even though many vaccines are developed, less number of vaccines only got the approval. Various covid 19 vaccines are available in India mainly covishield and covaxin. Vaccination for COVID-19 is very essential as&nbsp;&nbsp; vaccination&nbsp;&nbsp; has&nbsp;&nbsp; proved&nbsp;&nbsp; to&nbsp;&nbsp; decrease severity and prevent mortality due to COVID-19. All people should be vaccinated at the earliest to reduce the impact and severity of covid -19. so, information’s regarding covid -19 should be addressed to the public for removing the barriers which prevent them from taking vaccines. Many people are not yet vaccinated due to the misconceptions about vaccines and adverse events following immunization. This article contains a detailed review of vaccines currently available in India.</p> <p>Keywords: Covid -19, Vaccines, Adverse Events, Covaxin, Covishield, Immunisation</p> Subanthu Arya, K. Sreejith, V.K Thamanna, M. Salim Asna, Sabnam Maziya, Paul Kiran Mary Copyright (c) 2021 Journal of Drug Discovery and Therapeutics https://jddt.in/index.php/jddt/article/view/398 Tue, 05 Oct 2021 00:00:00 -0400 A Review on Various Gastro-Intestinal Effects of Mental Stress and Management https://jddt.in/index.php/jddt/article/view/399 <p>Stress is caused by the situation, person cannot capable to cope with that unfavourable event and person’s judgment not capable to suit the demand of that event. Symptoms of stress includes Depression, anxiety. Anger, irritability, restlessness. Feeling overwhelmed, unmotivated, or unfocused, Trouble sleeping or sleeping too much, Racing thoughts or constant worry, Problems with your memory or concentration, Making bad decisions etc. The physiological actions in gut are controlled by the Enteric nervous system [ part of central nervous system]. ENS carry millions of nerve cells as sensory motor and interneurons. They have sympathetic and para-sympathetic links. After the stress stimulus is delayed and reach Hypothalamic- pituitary – adrenal axis [ HPA axis] is producing Corticotrophin Releasing Factor (CRF). It directly produces some effects on gut like Changes in permeability of gut, Hypersensitivity to pain in visceral portion of gut, Increase chance of inflammation, Changes in gut motility, Gut microbiota transformation etc. The gastro-intestinal diseases like peptic ulcer, GERD, Inflammatory bowel disease, Irritable-bowel syndrome are produced. Techniques likes Yoga, meditation, physical exercises produce prevention and reduction of stress. In case of gastro- intestinal disorders some anxiolytics, ulcer- protectives, food changes can manage complications.&nbsp;</p> <p><strong>Keywords:</strong> Psychological stress, gastro-intestinal effects, Cortisol, Management techniques.</p> Paul Kiran Mary, K Sreejith, Subanthu Arya, V K Thamanna, M Asna Salim, Sabnam Maziya Copyright (c) 2021 https://jddt.in/index.php/jddt/article/view/399 Mon, 04 Oct 2021 00:00:00 -0400 A Review on Focal Problems of Breast Cancer Treatment and the Need for Rehabilitation https://jddt.in/index.php/jddt/article/view/400 <p>Breast cancer is the most malignant cancer in women around the globe. With the advent of diagnostic tools and novel methods of therapy, the mortality rate is now under control and the number of breast cancer survivors has improved. But unfortunately, the local therapies cause serious after effects like persistent pain in the breast area, arm and shoulder, lymphedema and restrictions of arm and shoulder movement. It can also cause psychological and social problems.Unfortunately, little attention has been paid to late effects of breast cancer that can persist for several years. This not only has diminished the quality of life of patients but also have increased the cost of life.&nbsp; In this article, we focus on the management of breast cancer and the focal problems associated with the same. Also we discuss about the need for rehabilitation and the type of rehabilitation techniques.</p> <p><strong>Keywords</strong>: Breast cancer, late effects of breast cancer, rehabilitation</p> M.Salim Asna, K Sreejith, Subanthu Arya, V.K Thamanna, Sabnam Maziya, Paul Kiran Mary Copyright (c) 2021 https://jddt.in/index.php/jddt/article/view/400 Thu, 07 Oct 2021 00:00:00 -0400 A REVIEW ON SELF MEDICATION IN GERIATRICS https://jddt.in/index.php/jddt/article/view/401 <p>Self medication is the practice of using drugs without doctor’s prescription. Nowadays this behavior is growing widely among people and the prevalence is high. As increasing age, body changes can affect the way medicines are absorbed and used. Geriatric population are more prone to use self medication practice due to lack of knowledge and commonly used for diseases like allergic rhinitis, common cold, osteoarthritis, heartburn, insomnia, constipation etc. Polypharmacy should be avoided. In situations where communication is lacking and the patient may receive medications from multiple prescribers for similar conditions, polypharmacy is particularly likely to occur. There is a need to develop a treatment infrastructure that is sensitive to problems of older substance users. This should include education of professionals as well as that of the public at large.</p> <p><strong>Keywords: </strong>self medication practice, polypharmacy, multimorbidity, pathogen resistance</p> V.K. Thamanna, K. Sreejith, Subanthu Arya, M.Salim Asna, Paul Kiran Mary, Sabnam Maziya Copyright (c) 2021 https://jddt.in/index.php/jddt/article/view/401 Thu, 07 Oct 2021 00:00:00 -0400