Pharmacological evaluation of 2-chloro substituted thiophene compound for anti-inflammatory activity in rats

Abstract

Introduction: Inflammation is a phenomenon associated with almost every disease process. It has always been a challenge to halt the inflammatory process with various drugs and to identify a drug with least side effects. In this study, 2-chlorothiophene was evaluated for its anti-inflammatory activity as an attempt in pursuit for a new ideal agent. Methods: Wistar albino rats were used in the study. Anti-inflammatory activity for acute phase was assessed by carrageenan induced paw edema model and cotton pellet induced granuloma model for chronic inflammation. Results: 2-chloro thiophene showed significant dose dependent anti-inflammatory action. At 20 mg/kg dose, it showed 84.62 % reduction in edema volume in acute phase which was superior to indomethacin. In chronic model the test drug at 20mg/kg showed 27.73% reduction in cotton pellet induced granuloma weight. The results were statistically significant with P<0.05. Conclusions: 2-chloro thiophene was found to possess significant anti-inflammatory properties for both acute and chronic inflammation and can be a promising anti- inflammatory agent.

Key words: thiophene, 2-chlorothiophene, anti-inflammatory, carrageenan, cotton pellet.