Application of metal complexes of schiff base with special reference to thiosemicarbazone: a review

Abstract

Schiff bases have been shown to exhibit a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Thiosemicarbazone derivatives are used in organic synthesis and they are used in evaluating new product that possesses different biological activities. This review covers updated information on the most active Thiosemicarbazone derivatives that have been reported to show considerable pharmacological actions such as, anticonvulsant, antidepressant and other biological activity. The Chemistry of Schiff bases is a field that is being no- ticed. Schiff base ligands are considered privileged li- gands because they are easily prepared by a simple one pot condensation of an aldehyde and primary amines. In this review, the synthesis, biological activities along with application of Schiff base and their complexes are summarized from 1976-2013.

Key words: Schiff Bases; Metal Complexes; Thiosemicarbazone; Antibacterial; Biological Activities