Dendrimer as a carrier for ocular drug delivery

Abstract

The foremost challenges face by today’s researcher is ocular drug delivery. Delivery of drug to the targeted ocular tissue is restricted by various ocular barriers. To conquer the ocular drug delivery barriers and get better ocular bioavailability, different conventional and novel drug delivery agents have been used. Dendrimer act as a drug delivery agent for promising, safe and selective drug delivery option. It’s extremely high selective nature for target the desired amount of drug to the tissue is most essential property and holds a promising future for the treatment of various ophthalmic diseases. Dendrimer shows physiochemical properties like pH, osmolality, and viscosity etc that are more compatible with ocular dosage form to formulate different formulations for ocular diseases. The important advantages of dendrimer in ocular drug delivery are persistence in corneal residence time, which can improve the bioavailability of drug, and introduce in the form of eye drops. Dendrimers help in achieving increased bioavailability, sustained, controlled as well as targeted release of drug.

Keywords: dendrimer, bioavailability, ocular drug delivery, hydrogels.