Medicated chewing gum: modern approach to improve mucosal drug delivery system- a review

Abstract

In current years technological advancements have been made in the research and development of oral drug delivery systems. It is considered to be a potential and convenient modified release drug delivery system which can be used in pain relief medication, smoking cessation, travel sickness, freshening of breath, avert of dental caries, mitigation of xerostomia, vitamin or mineral companion etc. Medicated chewing gums are solid, single dose making with a base consisting mainly of gums that are intended to be chewed but not swallowed. It is a potentially valuable means of administering drugs either locally or systematically via, the oral cavity. Chewing gum known as gum base (insoluble gum base resin) contains elastomer, emulsifiers, fillers, waxes, antioxidants, softners, sweeteners, food colorings, add to flavor agents, and in case of medicated chewing gum, active contents. An In-vitro apparatus was specially designed and constructed for release testing of medicated chewing gums.

Keywords: Oral drug release, medicated chewing gum, patient, sickness, xerostomia.