FORMULATION DEVELOPMENT AND CHARACTERIZATION OF FAST DISSOLVING ACETAMINOPHEN TABLETS

Abstract

The aim of the present work is to formulate a tablet which disintegrate and dissolve rapidly and give its rapid onset of action. Acetaminophen is an analgesic, antipyretic drug having bitter taste. In present study an attempt had been made to formulate rapidly disintegrating tablets of acetaminophen with altered taste by using directly compressible grade excipients which makes the formulation directly compressible with adequate mechanical strength and various superdisintigrants like Crospovidone, Sodium starch glycolate, Croscarmellose sodium along with incorporating sweetening agent. The tablets were evaluated for weight variation, hardness, friability, disintegration time, wetting time, in vitro dissolution studies and drug content. It was concluded that the batch prepared by using combination of Crospovidone and Sodium starch glycolate superdisintigrants shows excellent disintegration time, enhance dissolution rate, taste masking.

KEYWORDS: Acetaminophen, Fast dissolving tablet (FDT), Superdisintigrants, Direct compression