A REVIEW ARTICLE ON DENDRIMER TOXICITY

Authors

  • Sant Lal Department of Pharmacy, Rameshwaram Institute of Technology & Management, Lucknow, India

Abstract

ABSTRACT
PAMAM Dendrimer is highly branched polymer with low polydispersity and water soluble. The cationic Dendrimer are highly toxic to as the comparison of anionic Dendrimer with high generation (G5, G6, G7) Dendrimer. The toxicity caused by the high generation of Dendrimer is more as the comparison to low generation of Dendrimer.
The following Dendrimer toxicity is reported that mortality, sub lethal toxicity, hatching effect shown in the zebrafish and also caused cytotoxicity in blastomers in zebrafish. In the lethal toxicity like as reduce the body weight, bent trunk, small head and eye.
The PAMAM Dendrimer toxicity also reported that haemolytic, change the erythrocyte shape. Also reported that haemobilia and spleenomegaly (inlargment of spleen) with the high generation of Dendrimer G7 with 500mg/Kg orally dose.

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Published

2017-06-30

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Section

Articles