ASSESSMENT OF CPK, SERUM CREATININE AND eGFR IN PATIENTS WITH HYPOTHYROIDISM ON PRE AND POST TREATMENT IN A TERTIARY CARE TEACHING HOSPITAL
Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone or, more rarely, from their impaired activity at tissue level. This study was designed to estimate the creatine phosphokinase(CPK), serum creatinine level and estimated glomerular filtration rate(eGFR) in hypothyroidism cases and to assess the correlation with T4 and TSH. This Study included 62 patients of hypothyroidism. There is a significant alteration in creatine kinase, creatinine, and estimated GFR(eGFR) in hypothyroid patients which may be due to renal and muscular damage resulting in renal failure and myopathies. Our study adds to the existing knowledge, the importance of periodic assessment of renal parameters and creatine kinase in hypothyroid patients and effect of hypothyroid treatment on these biochemical parameters.
Keywords: Creatine phosphokinase,Serum creatinine, Estimated glomerular filtration rate,Thyroid stimulating hormone ,Tetraidothyronine, Hypothyroidism