FORMULATE AND EVALUATE DISPERSIBLE TABLET OF ACECLOFENAC FOR ENHANCEMENT OF BIOAVAILABILITY

Authors

  • Satya Prakash Chand Kaushik Chand Kaushik M.Pharm. Research Scholar, Department of Pharmaceutics, Jaipur College of Pharmacy, Jaipur, Rajasthan, India

Keywords:

Aceclofenac, Dispersible tablet, In vitro dispersion time, dry granulation, wet granulation

Abstract

The solubility was carried out in different solvents like methanol, ethanol and water. A pinch of drug was added into separate test tubes, containing 5 ml of each solvent. All the test tubes were shaken for 5-10 min. The UV absorbances of the solutions after appropriate dilutions were determined at 273 nm aceclofenac respectively (Shimadzu-1700 UV-visible spectrophotometer). Solutions of aceclofenac were prepared in the different dissolution medium and organic solvents. λmax was determined by scanning between 200-400 nm, using Shimadzu spectrophotometer. Capillary fusion method was used to determine the melting point of aceclofenac. The IR analysis of the sample was carried out for qualitative compound identification.Dispersible tablet of Aceclofenac was formulated using 2 % and 4 % of disintegrants Crospovidone, Sodium starch glycolate, Guar gum and Ispaghula by conventional dry granulation. Tablets were made from blends by direct compression, dry granulation and wet granulation methods. The quality of tablet, once formulated by rule, is generally dictated by the quality of physicochemical properties of blends. Twenty tablets were selected in a batch for the determination of thickness variation with Vernier Caliper. The weight of the tablet was measured with the help of digital electronic balance Hardness of tablet was determined using Pfizer tester. Friability of the tablets was determined using Roche friabilator. In vitro dispersion time was measured by dropping a tablet in a measuring cylinder containing 6 ml of water. Three tablets from each formulation were randomly selected and in vitro dispersion time was performed, the time that takes a tablet to disintegrate is measured by USP/ NF devices which contained glass tubes that are three inches long open at the top and held against a 10 mesh screen at the bottom end of the basket rack assembly. In vitro dissolution studies for all the fabricated tablets, marketed formulation and pure drug was carried out using USP paddle method at 75 rpm in 900 ml of phosphate buffer pH 7.0 as dissolution media, maintained at 37° ± 0.5.

KEY WORDS: Aceclofenac, Dispersible tablet, In vitro dispersion time, dry granulation, wet granulation

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Published

2018-02-27

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Articles