METHEMOGLOBINEMIA (METHBA): ONE OF WORLD’S MOST ULTRA- RARE SILENT KILLER

Authors

  • Kushal Nandi Department of Pharmaceutical Chemistry & Pharmacognosy, School of Pharmacy, Techno India University, Salt Lake City, Sector‒V, EM‒4, Kolkata‒700091, West Bengal, India.
  • Sandip Sarkar Department of Pharmaceutical Chemistry & Pharmacognosy, School of Pharmacy, Techno India University, Salt Lake City, Sector‒V, EM‒4, Kolkata‒700091, West Bengal, India.
  • Suprodip Mondal Department of Pharmaceutical Chemistry & Pharmacognosy, School of Pharmacy, Techno India University, Salt Lake City, Sector‒V, EM‒4, Kolkata‒700091, West Bengal, India.
  • Dhrubo Jyoti Sen Department of Pharmaceutical Chemistry & Pharmacognosy, School of Pharmacy, Techno India University, Salt Lake City, Sector‒V, EM‒4, Kolkata‒700091, West Bengal, India.
  • Dhananjoy Saha Deputy Director, Directorate of Technical Education, Bikash Bhavan, Salt Lake City, Kolkata‒700091, West Bengal, India.
  • Sarani Saha Department of Pharmaceutical Chemistry & Pharmacognosy, School of Pharmacy, Techno India University, Salt Lake City, Sector‒V, EM‒4, Kolkata‒700091, West Bengal, India.

Keywords:

Congenital Methemoglobinemia, Benzocaine

Abstract

Known more commonly as blue skin disorder, this disease is characterized by an abnormal amount of methemoglobin, a type of hemoglobin that's transformed to carrying iron, in a person's blood. Most of us have less than 1% methemoglobin in our blood stream, whereas those who suffer from blue skin disorder possess between 10% and 20% methemoglobin. Because iron-carrying hemoglobin carries only a reduced amount of oxygen, patients diagnosed with methemoglobinemia are at higher risk of developing heart abnormalities, having a seizure, or even dying prematurely. The disease has been made most famous by a single family in Kentucky who appear to have passed the genetic trait onto its family members for some 200 years.

Keywords: Congenital Methemoglobinemia, Benzocaine

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Published

2021-02-07

Issue

Vol. 9 No. 2 (2021)

Section

Articles