Psycosis and Antipsycotic Drug- A Review


  • Sheetal Yadav Sagar Institute of Pharmaceutical Sciences, Sagar M.P.470228
  • Akash Sharma Sagar Institute of Pharmaceutical Sciences, Sagar M.P.470228


Adherence,, Antipsychotics, Attitude toward medication, Bipolar disorder, Schizophrenia, Substance abuse


Conventional antipsychotic drugs, used for a half century to treat a range of major psychiatric disorders, are being replaced in clinical practice by modern “atypical” antipsychotics, including aripiprazole, clozapine, olanzapine, quetiapine, risperidone and ziprasidone among others. As a class, the newer drugs have been promoted as being broadly clinically superior, but the evidence for this is problematic. In this brief critical overview, we consider the pharmacology, therapeutic effectiveness, tolerability, adverse effects and costs of individual modern agents versus older antipsychotic drugs. Because of typically minor differences between agents in clinical effectiveness and tolerability, and because of growing concerns about potential adverse long-term health consequences of some modern agents.