Solubility Enhancement of Furosemide Drug using Self Emulsifying Drug Delivery System
Present experimental work was aimed, to prepare optimized, stable Solid self-emulsifying drug delivery system containing Furosemide drug.
The combination of the various solubilizer and hydrophilic surfactants like Poloxamer 188, polysorbate 80 and Medium chain triglycrides were used in the present study. PEG-40 Hydrogenated Castor Oil was used as solvent cum co surfactant on the basis of solubility of Furosemide. The formulations were so designed that they form nano dispersion on contact with water or GI fluids which increases the permeability through GI membrane.
All the prototype formulation tested for in vitro dissolution formed nano emulsion in 15 min. In case of the optimized formulation where the drug dissolution enhances with time indicating good thermodynamic stability of nanoemulsion produced on contact with aqueous fluids.
Keywords: Furosemide, PEG-40, Self Emulsifying Drug Delivery system.