Toxicity Study and Anti-Diabetic Activity of Indeginious Medicinal Herb Momordica Charantia

Abstract

Momordica charantia IS used as traditional medicines to treat diabetes mellitus.  The current study is done on treatment of diabetes mellitus with various herbal plants of Maharashtra region. Initially acute toxicity studies were performed, and diabetes is induced in rats with alloxane and streptozocin in laboratory. Alloxan induced diabetes is like type I diabetes due to deficiency of insulin in the body because of no release of insulin and type II diabetes is studied on the basis of hyperglycemia or obesity of the patients. These are treated with different plant extracts and comparison is done with standard antidiabetic drug.

The two most important plants are selected from Maharshtra vidharbha region and this is also found all over the country and most widely utilized for controlling sugar and lipid profile. Here these plants and their toxicity were studies for antidiabetic purpose. Karela fruits and seeds are useful constituents for extraction and isolation of active constituents.

Keywords: momordica charantia, diabetes,, extraction and evaluation, toxicity, anti-diabetes evaluation..