Formulation and Evaluation of Cinnarizine Floating Tablet Dosage form for Improved Absorption of Cinnarizine

Abstract

The purpose of this research was to prepare a floating drug delivery system of cinnarizine in order to increase the gastric residence time for enhance solubility in gastric HCL because of cinnarizine have lower solubility in intestine. Cinnarizinefloating tablet prepared by direct compression method using HPMC K4M as matrix formers, sodium bicarbonate as gasgenerating agent. The formulated tablets were evaluated for physical characteristics such as weight variation, hardness,friability, floating lag time and total floating time. The in-vitro release of the tablets was evaluated in 0.1N HCl for 10hrs. The drug release kinetic was fitted in three different mathematical models like- zero order, first order, Higuchi model. Amongst all the formulations, F2 and F3 were found to be better formulations and both contain same concentration of HPMC K4M (100 mg) with different concentrations of sodium bicarbonate (30 mg and 45 mg respectively). Formulation F2 and F3 showed 93.85% and 96.32% drug release at 10 hrs. Thus, it may be concluded that the cinnarizine floating tablet can be successfully formulated for improve absorption of cinnarizine with increase in the gastric residence time.

Keywords: Floating Tablet, Cinnarizine