A Research on Formulation, Characterization and Evaluation of Pre-Formulation Studies and Pre - Compressional Parameters of Anti -Hypertensive Drug Losartan Potassium by using Locust Bean Gum as Super-Disintegrant

Abstract

Patients who struggle to swallow pills, capsules, or other oral medications might find relief using fast-dissolving drug delivery devices. Fast-dissolving pills can be eaten without the assistance of water since they dissolve instantly in the mouth. The purpose of the current work was to use locust bean gum as a natural super disintegrant in pre-formulation trials of the medication losartan potassium. Conduct pre-formulation research on the drug's identification, solubility, and partition coefficient. Precompressional characteristics, such as angle of repose, swelling index, and micromeritic properties, can have an impact on tablet formulation in addition to the drug's characterisation, compatibility, and melting point.

Material and methods: Losartan potassium was received as gift sample from Elfin drug pvt ltd baddi, nalagarh (Himachal Pradesh). Locust bean gum was purchased from Lucid colloids, Mumbai. Microcrystalline cellulose (avice1102), aspartame and magnesium stearate was received as gift sample from helios pharmaceutical pvt. ltd. baddi (H.P). Menthol was purchased from Yarrow Chem. Mumbai (Maharashtra) and talc was purchased from Qualichems Fines Chemicals ltd New Delhi.

Result: The results suggested that locust bean gum in 7.5% concentration possess excellent super disintegrant property and resulted in fast dissolving tablets. Swelling index was found to be 22 which indicated appreciable capability of locust bean gum to be used as super disintegrant. IR spectra and DSC study showed that there was no any kind of interaction with formulation additives of the tablets.

Conclusion: Based on the pre formulation studies locust bean gum show a super disintegrant properties and it is clear that we can formulate fast dissolving antihypertensive tablet with losartan potassium by using locust bean gum as superdisintegrant.

Key words: Super disintegrant, preformulation, fast dissolving tablets (FDT_S), locust bean gum, losartan potassium.