A Research on Formulation Development of Sustained Release Antiulcer Drug Nizatidine and Study of Pre-Formulation Parameters and Its Evaluation
Keywords:
Kollidon SRAbstract
The current study's objective was to create sustained release tablets containing 220 mg of nizatidine by adjusting the concentration of polymers such as chitosan, HPMC K100M, and Kollidon SR using a wet granulation approach. The drug's melting point, FTIR analysis, and DSC analysis were among the pre-formulation factors that were investigated. Pre-compression characteristics such as bulk density, taped density, carry index, and angle of repose were assessed. The concept on how the concentration of polymers influences the drug formulation's pre-compression parameters was made clear by this study.
Keywords: Pre-formulation, characterization, Sustained Release, Antiulcer Drug, Nizatidine, Chitosan, HPMC K100, Kollidon SR.