Synthesis, Characterization and Anti-Convulsant Activity of Novel Substituted Oxadiazole Derivatives

Abstract

Seizures are sudden, transitory, and uncontrolled episodes of brain   dysfunction resulting from abnormal discharge of neuronal cells with associated motor, sensory or behavioral changes. Anticonvulsants (also commonly known as antiepileptic drugs or as antiseizure drugs) are a diverse group of pharmaceuticals used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder, since many seem to act as mood stabilizers, and for the treatment of neuropathic pain. Anticonvulsants suppress the rapid and excessive firing of neurons during seizures. Anticonvulsants also prevent the spread of the seizure within the brain. Substituted Oxadiazole derivatives synthesized by Hydrazination, formation, Cyclization process, Nitration and then evaluated for anti-convulsant activity.

The purity of all compounds have been checked by the TLC monitoring and the conformation of structure will be checked by different spectra like IR, Mass and NMR and evaluated for antimicrobial activity by calculate zone of inhibition. In conclusion, we have found some of the compounds prepared in course of this investigation are effective than the standard drug and some of them are found to be as active as the standard drug.

Key Words:- Oxadiazole , Oxadiazole derivatives, convulsion, , Anti-convulsant  activity...