SYTHESIS AND CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL SUBSTITUTED INDOLE DERIVATIVES

Abstract

Today inflammation is becoming one of the major roots of all the disease leading to various pharmacological complications. Majorly anti-inflammatory drugs given to patients are NSAIDs. But they also have major side effects that initiated the work for developing safer drugs. Research is a continuous and a never ending process. Efforts are being made to synthesize and formulate newer drugs having ideal pharmacological parameters with least side effects. The present assessment is just a minor effort to synthesize a better drug in the class of anti-inflammatory agents. As a part of my dissertation work, synthesis of indole derivatives for anti-inflammatory activity is an interesting task because in present NSAIDs there does exists any drug that has inculcated indole scaffold . Since the ongoing research work favors the indole moiety for the anti-inflammatory activity, it guided me on the same path to research on the novelty of indole. Further after synthesizing the designed drug the purity of the all the intermediates and final compounds will be TLC monitored whereas structure conformation will be analyzed by IR, Mass spectroscopy and NMR. Synthesized drugs were pharmacologically screened by the carrageenan induced rat paw edema method. Some results also supported the research by inhibiting the inflammation.

Keywords: - Indole, Anti-inflammatory activity, Indole derivatives, NSAIDs.