A Critical Review of Orodispersible Tablet Technologies: From Taste-Masking to Personalized 3d-Printed Drug Delivery Systems

Abstract

Orodispersible tablets (ODTs) represent a paradigm shift in oral drug delivery, enabling rapid disintegration and administration without water. The field has experienced rapid transformation in 2025 through continuous manufacturing, advanced taste-masking strategies, next-generation co-processed excipients, and the emergence of personalized 3D printing. ODTs have evolved beyond simple patient compliance tools toward sophisticated, patient-centric, and precision-engineered delivery systems. This review critically examines the latest technological and clinical advances in ODTs, including AI-driven design, nanotechnology integration, regulatory evolution, clinical applications, market trends, and future perspectives. The review synthesizes recent data, case studies, and regulatory updates, providing valuable insights for scientists, formulators, clinicians, and pharmaceutical stakeholders committed to advancing oral drug delivery technologies.

Keywords: Orodispersible tablets, ODT, taste-masking, co-processed excipients, personalized medicine, 3D printing, pharmaceutical manufacturing, and patient-centric design.