Hepatoprotective effect of Curcuma amada rhizome extracts against Paracetamol induced liver injury in rats

Abstract

The purpose of this study was to examine the hepatoprotective efficacy of Curcuma amada rhizome extracts against Paracetamol induced liver damage in rats. Wistar albino rats were orally fed 500 mg/kg of body weight of Methanolic and Hydroethanolic Curcuma amada rhizome extract, with Silymarin serving as the reference. By restoring functional parameters, physical parameters, biochemical parameters, and decreasing blood enzymes alkaline phosphatase (ALP) and total bilirubin (TBL) in the selected animal, the methanolic and hydroethanolic extracts exhibited a potent hepatoprotective effect. The plant's chemical composition includes, among others, alkaloids, flavonoids, glycosides, steroids, terpenoids, phenolics, and saponins. The overall experimental data suggest that bioactive phytoconstituents, such as flavonoids and alkaloids, present in the Methanolic and Hydroethanolic extracts of Curcuma amada rhizome may be responsible for the plant's significant hepatoprotective effect. The results thus support the use of Curcuma amada as a hepatoprotectant.

Keywords: Carbon tetrachloride, Hepatoprotective activity, Curcuma amada rhizome