Solubility Enhancement of BCS Class II Drug by Complexation using Cyclodextrins

Abstract

Complexation is the method by which solubility of drug substances can be improved by forming a complex between the drug substance and a complexing agent. Complex formation between the drug molecule and complexing agent increases the solubility of the drug by its improved dispersibility in the solvent. Complexing agents have the ability to form stable complexes with the drug substance through non-covalent interactions such as Van der Waals forces, hydrogen bonding, or electrostatic interactions. Several mechanisms are usually involved for such interaction, such as enhancing the polarity of the solvent system, reduction in the crystal lattice energy of the drug substance or decreasing the intermolecular forces among drug molecules. Complexing agents used in pharmaceutical formulations commonly include cyclodextrins, amino acids such as lysine & arginine and polymeric compounds such as polyvinylpyrrolidone (PVP). In the present study solubility and release properties of Celecoxib were tried to enhance by complexation with the βCD & HPβCD.  

Keywords: Celecoxib, Complexation, Cyclodextrin