Evaluation of neuroprotective activity of Tagetes erecta on 6-hydroxy dopamine induced neurotoxicity

Abstract

The present study evaluates the neuroprotective potential of Tagetes erecta extracts against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in Wistar rats. Methanolic (METE), ethanolic (EETE), and aqueous (AETE) extracts were administered orally at doses of 250 and 500 mg/kg for 21 days prior to induction of neurotoxicity. Behavioral assessments including locomotor activity and motor coordination (rota rod test) were conducted. 6-OHDA administration significantly impaired locomotor functions and muscle coordination, as evidenced by reduced square crossings, rearing, grooming, and retention time. Pretreatment with Tagetes erecta extracts significantly and dose-dependently improved these behavioral parameters. Among all treatments, higher doses (500 mg/kg) showed more pronounced neuroprotection. The findings suggest that Tagetes erecta possesses significant neuroprotective activity, possibly due to its antioxidant properties, and may be beneficial in managing neurodegenerative disorders.

Keywords: Tagetes erecta , Neuroprotection, 6-Hydroxydopamine (6-OHDA), Locomotor activity, Rota rod test