NEW SPECTROPHOTOMETRIC DETERMINATION OF PREGABALIN BULK AND PHARMACEUTICAL DOSAGE FORM

Abstract

A new, selective and sensitive visible spectrophotometric method have been developed for the estimation of Pregabalin in bulk and  pharmaceutical preparations.  The method is based on the reaction of pregabalin with 2, 3-dichloro-5, 6-dicyano-1, 4-benzquinone (DDQ) to form  red colour charge–transfer complex with a λmax. 465nm extracted in methanol. Beer’s law is obeyed in the concentration range of 50 to 250µg/ml for the method.  The method is extended to pharmaceutical formulations and there was no interference form any common pharmaceutical excepients and diluents.  The result of analysis has been validated statistically and by recovery studies. 

KEYWORDS: Spectrophotometric determination, DDQ, pregabalin