Cubosomes in Transdermal Drug Delivery System

Abstract

Cubosomes are spherical, cubic particles characterized by an internal cubic lattice. Cubosomes possess an extensive interfacial area and feature two internal aqueous channels divided by honeycombed features. They exhibit thermodynamic stability. The cubic liquid crystalline particles are known as cubosomes. These particles consist of particular surfactants, which have a unique microstructure, making them useful and possessing an ideal water content ratio. The cubic liquid crystalline phase is transparent, highly viscous, and features a distinctive nanoscopic structure. "Bicontinuous" indicates a lipid bilayer assembled in a space-filling system separating two continuously existing but not overlapping aqueous regions. Cubosomes are usually created through hydration of either a polar lipid or a surfactant, generating the cubic phase and dispersing the solid-like phase into tiny particles. From the time of their discovery and naming, cubosomes self-assembled have attracted considerable attention as potent drug delivery systems. They have distinct drug-loading mechanisms and different cubic shapes and composition inside. Their properties include high internal surface area, cubic crystalline structures, lipids' biodegradability, encapsulation of hydrophobic, hydrophilic, and amphiphilic compounds, targeted delivery, and bioactive substance release. Cubosomes can be classified using several evaluation parameters and have broad applications in diverse fields. Cubosomes are consequently garnering heightened interest within the pharmaceutical sector.

Keywords: amphiphilic, hydrophilic, hydrophobic, drug-loading,