Formulation and Evaluation of Solid Lipid Nanoparticles Containing Fenoprofen

Abstract

The biggest challenge up to date is to control the delivery rate of the medicaments by various modern technologies met by extensive research. However, TDS is not practical for delivery of materials whose final target is the skin itself. The oral administration of fenoprofen causes gastrointestinal ulcers and bleeding in chronic use. Due to gastrointestinal bleeding, it may cause anaemia. Also, use of fenoprofen is limited by its poor solubility and low bioavailability. Thus,  the  present study  aimed  at  design  and  development of a drug delivery system which could  enhance  the  solubility  of  fenoprofen.

Keywords: Gastrointestinal, Bioavailability, Fenoprofen