Development and Evaluation of Nanogel Formulation of Telmisartan-amlodipine Combined Dosage form

Abstract

Hypertension remains a leading global health challenge, with poor patient compliance and low bioavailability of conventional antihypertensive drugs contributing to suboptimal blood pressure control. Nanogel-based drug delivery systems offer a promising approach to enhance solubility, stability, and sustained release of antihypertensive agents. This study reports the development and comprehensive evaluation of nanogel formulations containing amlodipine and telmisartan. Nine formulations (F1–F9) were prepared using Carbopol, chitosan, Tween 80, and ethanol. The optimized formulation (F5) demonstrated superior physicochemical properties, sustained drug release, and excellent stability over 45 days, highlighting its potential as an effective topical antihypertensive therapy.

Key words: Antihypertensive, Amlodipine, Telmisartan and Nanogel..