Spanlastics: An Innovative Nanovesicular Platform for Advanced Drug Delivery

Abstract

In recent years, researchers have increasingly focused on novel drug delivery systems to address limitations of conventional dosage forms, particularly for drugs with low solubility, poor bioavailability, and limited permeability. Traditional formulations such as liposomes, niosomes, and nanoparticles have been developed to improve drug delivery; however, they often face challenges related to flexibility, stability, and deformability. To overcome these drawbacks, spanlastics were introduced as an advanced vesicular system. Spanlastics are elastic, non-toxic vesicles capable of entrapping drugs within their core, offering controlled and targeted delivery. Their nanosized vesicles, referred to as nanospanlastics, enhance the bioavailability of poorly soluble drugs and provide improved stability compared to liposomes, niosomes, and conventional nanoparticles. These systems are particularly effective in delivering both hydrophilic and lipophilic drugs to specific sites, reducing side effects and improving therapeutic outcomes. This review highlights the classification, preparation methods, mechanisms, evaluation techniques, and diverse applications of spanlastics in modern drug delivery.

Keywords: Nanoparticles, Spanlastic, Method of Preparation, Applications